International Journal of
MediPharm Research

: Low aqueous solubility remains one of the dominant challenges limiting the clinical performance of modern drug molecules. As nearly 40% of marketed drugs and more than 70% of new chemical entities fall into Biopharmaceutics Classification System (BCS) Class II or IV, formulation scientists continue to seek reliable and scalable strategies to improve dissolution behavior and oral bioavailability. Liquisolid compact technology has emerged as a promising method capable of enhancing the dissolution performance of poorly water-soluble drugs by converting liquid medications into compressible, free-flowing powders. This review provides an expanded, in-depth evaluation of the scientific principles, technological advancements, excipient selection, formulation considerations, micromeritic evaluations, and performance outcomes associated with liquisolid systems. Mechanistic insights into wettability enhancement, increased surface area, and molecular drug dispersion are examined. Applications in sustained-release design, supersaturable systems, and solid-state transformation are highlighted. The review also synthesizes contemporary findings, discusses manufacturing scalability, and explores future directions involving nanotechnology integration and predictive computational modelling. The evidence suggests that liquisolid technology represents a versatile, cost-effective, and industrially feasible strategy for improving the pharmaceutical performance of challenging drug candidates. Keywords: Liquisolid compact technology; Solubility enhancement; Wettability; Molecular dispersion; Supersaturation.