International Journal of
MediPharm Research

Analgesic medications, while effective for pain relief, are associated with a range of side effects from mild discomfort to severe complications. Following surgical repair of fractures, analgesics are routinely prescribed, yet data on their adverse events specifically in ankle and hind foot fractures remain limited. This study aims to evaluate patterns of oral analgesic prescriptions post-surgery for these fractures, document the occurrence of adverse events, and identify potential risk factors. Methods: The study recruited 19 adult patients with traumatic ankle and hind foot fractures at a tertiary care hospital. Prescribed oral analgesics at discharge and at the one-week follow-up were recorded. Potential adverse events were monitored at one- and two-week follow-ups. Incidence rates were calculated, and relationships between adverse events, age, and gender were analyzed using logistic regression and correlation assessments. Results: The overall incidence of adverse events among the study population was 1.1 events per person-year across the 1- and 2-week follow-ups. Analgesic-specific analysis identified high-risk agents: acetaminophen alone or combined with diclofenac or tramadol was associated with increased cardiovascular risks (N=4.21%). Combinations such as naproxen with tramadol, orphenadrine with acetaminophen, and diclofenac were linked to gastrointestinal and central nervous system complications (N=3.16%). Conclusion: This study provides initial evidence on adverse event incidence linked to oral analgesic prescriptions for ankle and hind foot fractures, aiding in safer analgesic selection. Ongoing research will further refine patient specific pain management strategies and help establish fracture-specific protocols to optimize safety and efficacy. Keywords: Analgesics; Adverse events; Ankle fractures; Hind foot fractures; Pain management; Trauma