International Journal of
MediPharm Research

: Asthma is a chronic inflammatory disorder of the airways involving multiple cellular pathways and inflammatory mediators that collectively contribute to characteristic symptoms. This study evaluated the impact of a structured asthma-specific exercise program on interleukin-10 (IL-10), immunoglobulin E (IgE), and quality of life in individuals with persistent atopic asthma. Methods: This experimental study used a pre–post test design and included 39 participants who met predefined clinical inclusion criteria. IL-10 concentrations were measured from peripheral blood mononuclear cell supernatants, and plasma IgE levels were quantified using ELISA. Quality of life was assessed using the Asthma Quality of Life Questionnaire (AQLQ). Participants performed guided asthma exercises four times per week for eight weeks, with each session lasting 60 minutes. Data analysis included the Wilcoxon test and Spearman correlation. Results: The exercise intervention produced significant improvements, including increased IL-10 levels (p = 0.000), reduced IgE concentrations (p = 0.001), and enhanced quality-of-life scores (p = 0.000). Despite these positive changes, no significant correlations were observed between IL-10 and quality of life (p = 0.063), IL-10 and IgE (p = 0.280), or IgE and quality of life (p = 0.206). Conclusion: Asthma exercise effectively elevated IL-10, reduced IgE levels, and improved quality of life in individuals with persistent atopic asthma. However, the changes in inflammatory markers did not directly correlate with improvements in quality of life. Keywords: Asthma exercise; Interleukin-10; Immunoglobulin E; Quality of life.