International Journal of
MediPharm Research

ISSN 2395 - 423X

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Kajiram Adhikari
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Abstract

Synthesis, Characterization, Antimicrobial and Corrosion Inhibition Evaluation of Onno-Chelating Schiff Base Ligand and its Metal Complexes

YiheyisBogaleZemede, Nithyakalyani  D., AnandaKumar S.

ABSTRACT

A schiff base, (2E)-2-((5-((E)-(2-hydroxyphenylimino) methyl) thiophene-2-yl) methyl eneamino) phenol (L) and its metal complexes were synthesized and characterized via elemental analysis, Molar conductance, Magnetic susceptibility, TGA, IR, UV-Vis, 1H-NMR, MS-EI and EPR spectral data. Elemental analyses together with metal estimation confirmed a 1:1 [L]:[metal] ratio of the complexes. IR and electronic absorption spectra showed that the ligand coordinated with metal ions through azomethine-N and phenolic-O. Based on the spectral and analytical data, geometry of each complex was proposed. The schiff base and its metal complexes were screened for their in vitro antimicrobial activities against S. aureus, P. aeruginosa, A.hydrophila, C. albicans and C. krusei. With the exception against C. krusei, higher activities were exhibited upon coordination of the ligand with metal ions. Corrosion inhibition of the compounds was also evaluated using weight loss method in a 0.1MHCl solution for mild steel. It was found that the compounds had a promising inhibitory action against corrosion of mild steel. Keywords: Schiff base ligand; high-spin Octahedral; quadridentate, thermal stability; in vitro antimicrobial screening; Corrosion inhibition.

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