International Journal of
MediPharm Research

ISSN 2395 - 423X

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Kajiram Adhikari
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Abstract

UV Spectrophotometric Estimation of Diclofenac Potassium and Omeprazole Magnesium in Bulk and Combined Tablet Dosage Form

Tukaram Kalyankar, S.J. Wadher, Rameshwar Gholve, Anitha K

ABSTRACT

The aim of the present work is to develop simple, sensitive, accurate, precise and economic UV-spectrophotometric methods for the simultaneous estimation of diclofenac potassium and omeprazole magnesium in bulk and pharmaceutical tablet dosage form. The absorbance maxima (?max) for detection of diclofenac potassium and omeprazole magnesium were selected as 282.2 nm and 301.8 nm respectively for simultaneous equation method while wavelength range for detection of diclofenac potassium and omeprazole magnesium were selected as 280 nm - 285 nm and 300 mm - 305 nm respectively for area under curve method. Both the methods were found to be linear over the range of 5-30 µg/ml and 1-6 µg/ml for diclofenac potassium and omeprazole magnesium respectively and exhibited the correlation coefficient (r2) of 0.999.The developed methods were validated statistically according to ICH guidelines in terms of linearity, accuracy, precision, limit of detection and limit of quantitation.The degradation behavior of the diclofenac potassium and omeprazole magnesium were studied by subjecting to an acid, alkaline, neutral, oxidative, photolytic, sunlight and thermal degradation. Keywords: Diclofenac potassium, omeprazole magnesium, UV spectrophotometric method, validation, forced degradation.

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