International Journal of
MediPharm Research

ISSN 2395 - 423X

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Kajiram Adhikari
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Abstract

A Stability Indicating Validated Method for the Quantitation of hydrochlorothiazide by Using Diffuse Reflectance Infrared Fourier Transform Spectroscopy in bulk and tablet dosage form

S. J. Wadher, T. M. Kalyankar, M. P. Puranik and Swami Jayshri

ABSTRACT

A quantitative method using diffuse reflectance infrared fourier transform spectroscopy (DRIFTS) was developed and validated for the estimation of hydrochlorothiazide (HCTZ) in its tablet dosage form. The solid-state samples were, prepared by dilution in dry potassium bromide and were analyzed by FTIR spectrophotometer with DRIFT sampling technique. A linear relationship for the sulphone peak area centered on 1151 cm?1 was observed in the range of 1-6 % w/w with good correlation coefficient of 0.999. The percent recovery of hydrochlorothiazide in marketed tablet dosage form was in the range of 100 ± 0.3071. The present reported method is precise, reproducible, and eco-friendly. Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) may have a potential as an alternative method for qualitative and quantitative analysis of hydrochlorothiazide in bulk drugs and tablet dosage forms. Keywords: Hydrochlorothiazide, FTIR, Validation, Tablet, Infrared spectroscopy, Stability indicating method.

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