International Journal of
MediPharm Research

ISSN 2395 - 423X

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Kajiram Adhikari
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Abstract

Development and Evaluation of Superporous Hydrogel Tablets of Cefditoren Pivoxil as a Gastroretentive System

Sirisha Yella*, Dr. Avanapu Srinivasa Rao , Sravanthi Kalakonda

ABSTRACT

Superporous hydrogels(SPHs) were originally developed as novel drug delivery system to retain drugs in the gastric medium. These systems should instantly swell in the stomach and maintain their integrity in the harsh stomach environment, while releasing the pharmaceutical active ingredient. The present review focuses on concept of development of cefditoren pivoxil as superporous hydrogel tablets, their applications and various evaluation techniques.The aim of this study is to prepare Gastroretentive dosage form based on SPH using cefditoren pivoxil as a model drug for swelling & prolonged drug release characteristics in acidic pH. The formulation is based on preparation of third generation SPHs with three different polymers, such as, Formaldehyde, Urea-Formaldehyde and Sodium tripolyphosphate with chitosan as crosslinking agent were used with different concentrations by crosslinking technique to get the desired sustained release profile over a period of 8 hrs. The characterization studies for SPH were performed by measurement of apparent density, porosity, swelling studies, mechanical strength, scanning electron microscopy(SEM) and FT-IR.All formulations were evaluated for stability, drug content,kinetic drug release & invitro drug release profile. It is concluded that the proposed gastroretentive drug –deliverysystem based on SPHs is promising for stomach specific delivery of Cefditoren Pivoxil. Key Words: Gastroretentive dosage forms,Superporous hydrogels, chitosan, swelling, Cefditoren Pivoxil.

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